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Tailor ARV-based HIV prevention strategies in local contexts: Report

By • on June 20, 2013

To make an impact on new HIV infections globally, antiretroviral (ARV)-based HIV prevention strategies need to be closely tailored to local contexts and cultures, according to

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Effect of Landscape Structure on Species Diversity

By • on June 20, 2013

by Paulo R. A. Campos, Alexandre Rosas, Viviane M. de Oliveira, Marcelo A. F. Gomes The effects of habitat fragmentation and their implications for biodiversity is a central issue in conservation biology which still lacks an overall comprehension. There is not yet a clear consensus on how to quantify fragmentation even though it is quite common

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Stress Impact on Resting State Brain Networks

By • on June 20, 2013

by José Miguel Soares, Adriana Sampaio, Luís Miguel Ferreira, Nadine Correia Santos, Paulo Marques, Fernanda Marques, Joana Almeida Palha, João José Cerqueira, Nuno Sousa Resting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly,

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Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein

By • on June 20, 2013

by Laura E. Ott, Eui Jae Sung, Adam T. Melvin, Mary K. Sheats, Jason M. Haugh, Kenneth B. Adler, Samuel L. Jones Myristoylated alanine-rich C-kinase substrate (MARCKS) is a ubiquitously expressed substrate of protein kinase C (PKC) that is involved in reorganization of the actin cytoskeleton. We hypothesized that MARCKS is involved in regulation of

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Effects of Separate and Concomitant TLR-2 and TLR-4 Activation in Peripheral Blood Mononuclear Cells of Newborn and Adult Horses

By • on June 20, 2013

by Johannes Cornelis Vendrig, Luc Edgar Coffeng, Johanna Fink-Gremmels Deficient innate and adaptive immune responses cause newborn mammals to be more susceptible to bacterial infections than adult individuals. Toll-like receptors (TLRs) are known to play a pivotal role in bacterial recognition and subsequent immune responses. Several studies have

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Hagel Discusses ‘State of DOD’ in Nebraska Speech

By • on June 19, 2013

Hagel Discusses ‘State of DOD’ in Nebraska Speech By Karen ParrishAmerican Forces Press Service WASHINGTON, June 19, 2013 – In a wide-ranging speech given today at the University of Nebraska at Omaha, his alma mater, Defense Secretary Chuck Hagel talked about the necessity of adapting the nation’s military to operate in a world that’s

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A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury

By • on June 19, 2013

by Manuela Cervelli, Gabriella Bellavia, Marcello D’Amelio, Virve Cavallucci, Sandra Moreno, Joachim Berger, Roberta Nardacci, Manuela Marcoli, Guido Maura, Mauro Piacentini, Roberto Amendola, Francesco Cecconi, Paolo Mariottini Spermine oxidase is a FAD-containing enzyme involved in polyamines catabolism, selectively oxidizing spermine to produce

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Activation of GPER Induces Differentiation and Inhibition of Coronary Artery Smooth Muscle Cell Proliferation

By • on June 19, 2013

by Fen Li, Xuan Yu, Claudia K. Szynkarski, Cong Meng, Beiyan Zhou, Rola Barhoumi, Richard E. White, Cristine L. Heaps, John N. Stallone, Guichun Han Background Vascular pathology and dysfunction are direct life-threatening outcomes resulting from atherosclerosis or vascular injury, which are primarily attributed to contractile smooth muscle cells (SMCs)

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Bone Marrow Stem Cell Treatment for Ischemic Heart Disease in Patients with No Option of Revascularization: A Systematic Review and Meta-Analysis

By • on June 19, 2013

by Sheila A. Fisher, Carolyn Dorée, Susan J. Brunskill, Anthony Mathur, Enca Martin-Rendon Objective To evaluate bone marrow stem cell treatment (BMSC) in patients with ischemic heart disease (IHD) and no option of revascularization. Background Autologous BMSC therapy has emerged as a novel approach to treat patients with acute myocardial infarction

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Effects of Sex on Intra-Individual Variance in Urinary Solutes in Stone-Formers Collected from a Single Clinical Laboratory

By • on June 19, 2013

by Guy M. L. Perry, Steven J. Scheinman, John R. Asplin Background/Aims Our work in a rodent model of urinary calcium suggests genetic and gender effects on increased residual variability in urine chemistries. Based on these findings, we hypothesized that sex would similarly be associated with residual variation in human urine solutes. Sex-related

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