Cameron Diaz, Nick Cassavetes and the SISTER’S KEEPER Cast Talk Health Scares and Hard Decisions

Once again, The Notebook director Nick Cassavetes is serving up a heart-wrenching film that, aside from its box office prospects, just might help Kleenex through today’s tough economy.

My Sister’s Keeper – based on the bestselling book by novelist and recent Wonder Woman comic book scribe Jodi Picoult – re-teams Cassavetes with his Notebook collaborators, producer Mark Johnson and screenwriter Jeremy Leven, to tell the emotion-filled tale of two parents (Cameron Diaz and Jason Patric) who, when they discover their infant daughter Kate has leukemia, decide to conceive another child to provide genetic material in hopes of prolonging Kate’s life.

As they mature, the two sisters – Sophia Vassilieva as the afflicted Kate and Abilgail Breslin as her intended savior Anna – share an incredibly close bond. So close that when Anna hires a lawyer to medically emancipate herself, against her determined mother’s single-minded wishes, it threatens to tear the seemingly normal but already fraying family apart.