Sequencing by Hybridization of Long Targets

by Yu Qin, Tobias M. Schneider, Michael P. Brenner

Sequencing by Hybridization (SBH) reconstructs an n-long target DNA sequence from its biochemically determined l-long subsequences. In the standard approach, the length of a uniformly random sequence that can be unambiguously reconstructed is limited to due to repetitive subsequences causing reconstruction degeneracies. We present a modified sequencing method that overcomes this limitation without the need for different types of biochemical assays and is robust to error.

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Sequencing by Hybridization of Long Targets
Syndicated from:PLoS ONE

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