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Indirect Co-Culture with Tendons or Tenocytes Can Program Amniotic Epithelial Cells towards Stepwise Tenogenic Differentiation
by Barbara Barboni, Valentina Curini, Valentina Russo, Annunziata Mauro, Oriana Di Giacinto, Marco Marchisio, Melissa Alfonsi, Mauro Mattioli Background Amniotic epithelial cells (AEC) have potential applications in cell-based therapy. Thus far their ability to differentiate into tenocytes has not been investigated although a cell source providing
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A Morphometric Assessment of the Intended Function of Cached Clovis Points
by Briggs Buchanan, J. David Kilby, Bruce B. Huckell, Michael J. O’Brien, Mark Collard A number of functions have been proposed for cached Clovis points. The least complicated hypothesis is that they were intended to arm hunting weapons. It has also been argued that they were produced
Extra-Renal Elimination of Uric Acid via Intestinal Efflux Transporter BCRP/ABCG2
by Atsushi Hosomi, Takeo Nakanishi, Takuya Fujita, Ikumi Tamai Urinary excretion accounts for two-thirds of total elimination of uric acid and the remainder is excreted in feces. However, the mechanism of extra-renal elimination is poorly understood. In the present study, we aimed to
Post-Therapeutic Relapse of Psoriasis after CD11a Blockade Is Associated with T Cells and Inflammatory Myeloid DCs
by Leanne M. Johnson-Huang, Cara A. Pensabene, Kejal R. Shah, Katherine C. Pierson, Toyoko Kikuchi, Tim Lentini, Patricia Gilleaudeau, Mary Sullivan-Whalen, Inna Cueto, Artemis Khatcherian, Luke A. Hyder, Mayte Suárez-Fariñas, James G. Krueger, Michelle A. Lowes Trial registration Clinicaltrials.gov
Why Was the 2009 Influenza Pandemic in England So Small?
by Ruben J. Kubiak, Angela R. McLean The “Swine flu” pandemic of 2009 caused world-wide infections and deaths. Early efforts to understand its rate of spread were used to predict the probable future number of cases, but by the end of 2009 it was clear that these predictions had substantially
Bifidobacterium longum CECT 7347 Modulates Immune Responses in a Gliadin-Induced Enteropathy Animal Model
by José Moisés Laparra, Marta Olivares, Onofrio Gallina, Yolanda Sanz Coeliac disease (CD) is an autoimmune disorder triggered by gluten proteins (gliadin) that involves innate and adaptive immunity. In this study, we hypothesise that the administration of Bifidobacterium longum CECT 7347,
Genotypic Diversity Effects on the Performance of Taraxacum officinale Populations Increase with Time and Environmental Favorability
by Emily B. M. Drummond, Mark Vellend Within-population genetic diversity influences many ecological processes, but few studies have examined how environmental conditions may impact these short-term diversity effects. Over four growing seasons, we followed experimental populations of a clonal,
Virtual versus Physical Channel for Sex Networking in Men Having Sex with Men of Sauna Customers in the City of Hong Kong
by Shui-Shan Lee, Agnes N. S. Lam, Chi-Kei Lee, Ngai-Sze Wong Background Advances in communication technology may affect networking pattern, thereby influencing the dynamics of sex partnership. The aim of the study is to explore the impacts of partner sourcing through internet and related channels on
Multi-Gene Expression Predictors of Single Drug Responses to Adjuvant Chemotherapy in Ovarian Carcinoma: Predicting Platinum Resistance
by J. Stuart Ferriss, Youngchul Kim, Linda Duska, Michael Birrer, Douglas A. Levine, Christopher Moskaluk, Dan Theodorescu, Jae K. Lee Despite advances in radical surgery and chemotherapy delivery, ovarian cancer is the most lethal gynecologic malignancy. Standard therapy includes treatment
Immunization against Leishmania major Infection Using LACK- and IL-12-Expressing Lactococcus lactis Induces Delay in Footpad Swelling
by Felix Hugentobler, Karen K. Yam, Joshua Gillard, Raya Mahbuba, Martin Olivier, Benoit Cousineau Background Leishmania is a mammalian parasite affecting over 12 million individuals worldwide. Current treatments are expensive, cause severe side effects, and emerging drug resistance has been reported.