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Adaptation Shifts Preferred Orientation of Tuning Curve in the Mouse Visual Cortex
by Jeyadarshan Jeyabalaratnam, Vishal Bharmauria, Lyes Bachatene, Sarah Cattan, Annie Angers, Stéphane Molotchnikoff In frontalized mammals it has been demonstrated that adaptation produces shift of the peak of the orientation tuning curve of neuron following frequent or lengthier presentation of a non-preferred stimulus. Depending
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MACC1 as a Prognostic Biomarker for Early-Stage and AFP-Normal Hepatocellular Carcinoma
by Chan Xie, Jueheng Wu, Jingping Yun, Jiaming Lai, Yunfei Yuan, Zhiliang Gao, Mengfeng Li, Jun Li, Libing Song Background The metastasis-associated in colon cancer 1 gene (MACC1) has been found to be associated with cancer development and progression. The aim of this study was to investigate the prognostic
miR172b Controls the Transition to Autotrophic Development Inhibited by ABA in Arabidopsis
by Yanmin Zou, Youning Wang, Lixiang Wang, Lei Yang, Rui Wang, Xia Li Seedling establishment is a critical phase in the life of plants when they are the most vulnerable to environment. Growth arrest at post-germinative stage under stress is the major adaptive strategy to help germinating seedlings
How Ionic Strength Affects the Conformational Behavior of Human and Rat Beta Amyloids – A Computational Study
by Zdeněk Kříž, Jiří Klusák, Zdena Krištofíková, Jaroslav Koča Progressive cerebral deposition of amyloid beta occurs in Alzheimeŕs disease and during the aging of certain mammals (human, monkey, dog, bear, cow, cat) but not others (rat, mouse). It is possibly due to different amino acid
Dietary Glycemic Load and Glycemic Index and Risk of Cerebrovascular Disease in the EPICOR Cohort
by Sabina Sieri, Furio Brighenti, Claudia Agnoli, Sara Grioni, Giovanna Masala, Benedetta Bendinelli, Carlotta Sacerdote, Fulvio Ricceri, Rosario Tumino, Maria Concetta Giurdanella, Valeria Pala, Franco Berrino, Amalia Mattiello, Paolo Chiodini, Salvatore Panico, Vittorio Krogh Background Studies on
Ancestral Gene Organization in the Mitochondrial Genome of Thyridosmylus langii (McLachlan, 1870) (Neuroptera: Osmylidae) and Implications for Lacewing Evolution
by Jing Zhao, Hu Li, Shaun L. Winterton, Zhiqi Liu The first complete mitochondrial genome of the lacewing family Osmylidae (Thyridosmylus langii (McLachlan, 1870)) (Neuroptera) was sequenced in this study. The genome is a circular molecule of 16,221 bp containing the typical 37 genes but is arranged
Circulating miRNAs as Potential Marker for Pulmonary Hypertension
by Chuanyu Wei, Heather Henderson, Christopher Spradley, Li Li, Il-Kwon Kim, Sandeep Kumar, Nayeon Hong, Alejandro C. Arroliga, Sudhiranjan Gupta MircoRNAs (miRNAs) are small non-coding RNAs that govern the gene expression and, play significant role in the pathogenesis of heart failure. The detection
BcL-xL Conformational Changes upon Fragment Binding Revealed by NMR
by Clémentine Aguirre, Tim ten Brink, Olivier Walker, Florence Guillière, Dany Davesne, Isabelle Krimm Protein-protein interactions represent difficult but increasingly important targets for the design of therapeutic compounds able to interfere with biological processes. Recently, fragment-based strategies
Connectivity of the Habitat-Forming Kelp, Ecklonia radiata within and among Estuaries and Open Coast
by Melinda A. Coleman With marine protected areas being established worldwide there is a pressing need to understand how the physical setting in which these areas are placed influences patterns of dispersal and connectivity of important marine organisms. This is particularly critical for dynamic and
Genome-Wide Analysis of the Salmonella Fis Regulon and Its Regulatory Mechanism on Pathogenicity Islands
by Hui Wang, Bin Liu, Quan Wang, Lei Wang Fis, one of the most important nucleoid-associated proteins, functions as a global regulator of transcription in bacteria that has been comprehensively studied in Escherichia coli K12. Fis also influences the virulence of Salmonella enterica and pathogenic E.