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HIV Due to Female Sex Work: Regional and Global Estimates
by Annette Prüss-Ustün, Jennyfer Wolf, Tim Driscoll, Louisa Degenhardt, Maria Neira, Jesus Maria Garcia Calleja Introduction Female sex workers (FSWs) are at high risk of HIV infection. Our objective was to determine the proportion of HIV prevalence in the general female adult population that is attributable to the occupational exposure of female
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The Catalytic Roles of P185 and T188 and Substrate-Binding Loop Flexibility in 3α-Hydroxysteroid Dehydrogenase/Carbonyl Reductase from Comamonas testosteroni
by Chi-Ching Hwang, Yi-Hsun Chang, Hwei-Jen Lee, Tzu-Pin Wang, Yu-Mei Su, Hsin-Wei Chen, Po-Huang Liang 3α-Hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni reversibly catalyzes the oxidation of androsterone with NAD+ to form androstanedione and NADH. Structurally
Wicking: A Rapid Method for Manually Inserting Ion Channels into Planar Lipid Bilayers
by Justin A. Costa, Dac A. Nguyen, Edgar Leal-Pinto, Ronald E. Gordon, Basil Hanss The planar lipid bilayer technique has a distinguished history in electrophysiology but is arguably the most technically difficult and time-consuming method in the field. Behind this is a lack of experimental
Hydrogen Sulfide Donor NaHS Reduces Organ Injury in a Rat Model of Pneumococcal Pneumosepsis, Associated with Improved Bio-Energetic Status
by Hamid Aslami, Wilco P. Pulskens, Maria T. Kuipers, Aafkeline P. Bos, André B. P. van Kuilenburg, Ronald J. A. Wanders, Jeroen Roelofsen, Joris J. T. H. Roelofs, Raphaela P. Kerindongo, Charlotte J. P. Beurskens, Marcus J. Schultz, Wim Kulik, Nina C. Weber, Nicole P. Juffermans Sepsis is characterized
Practice-Based Evidence: Profiling the Safety of Cilostazol by Text-Mining of Clinical Notes
by Nicholas J. Leeper, Anna Bauer-Mehren, Srinivasan V. Iyer, Paea LePendu, Cliff Olson, Nigam H. Shah Background Peripheral arterial disease (PAD) is a growing problem with few available therapies. Cilostazol is the only FDA-approved medication with a class I indication for intermittent claudication,
Long Noncoding RNA HOTAIR Is a Prognostic Marker for Esophageal Squamous Cell Carcinoma Progression and Survival
by Xiao-Bin Lv, Gui-Yong Lian, Hao-Ran Wang, Erwei Song, Herui Yao, Ming-Hui Wang Background It is currently unclear whether the expression of HOX transcript antisense RNA (HOTAIR) correlates with the progression of esophageal cancer. The aim of this study was to examine HOTAIR expression in patients
Cytotoxicity of Tumor Antigen Specific Human T Cells Is Unimpaired by Arginine Depletion
by Markus Munder, Melanie Engelhardt, Diana Knies, Sergej Medenhoff, Guido Wabnitz, Claudia Luckner-Minden, Nadja Feldmeyer, Ralf-Holger Voss, Pascale Kropf, Ingrid Müller, Roland Conradi, Yvonne Samstag, Matthias Theobald, Anthony D. Ho, Hartmut Goldschmidt, Michael Hundemer Tumor-growth is often
Congruence and Diversity of Butterfly-Host Plant Associations at Higher Taxonomic Levels
by José R. Ferrer-Paris, Ada Sánchez-Mercado, Ángel L. Viloria, John Donaldson We aggregated data on butterfly-host plant associations from existing sources in order to address the following questions: (1) is there a general correlation between host diversity and butterfly species richness?, (2)
Tailored Education for Older Patients to Facilitate Engagement in Falls Prevention Strategies after Hospital Discharge—A Pilot Randomized Controlled Trial
by Anne-Marie Hill, Christopher Etherton-Beer, Terry P. Haines Background The aims of the study were to evaluate the effect of providing tailored falls prevention education in hospital on: i) engagement in targeted falls prevention behaviors in the month after discharge: ii) patients’ self-perceived
Validating Predictions from Climate Envelope Models
by James I. Watling, David N. Bucklin, Carolina Speroterra, Laura A. Brandt, Frank J. Mazzotti, Stephanie S. Romañach Climate envelope models are a potentially important conservation tool, but their ability to accurately forecast species’ distributional shifts using independent survey data has not